Protein Synthesis Inhibitors Flashcards | Quizlet Protein Synthesis Inhibitors Flashcards | Quizlet

Do macrolides inhibit protein synthesis, you must create an account to continue watching

In infants the use of erythromycin has been associated with pyloric stenosis.

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Tetracyclines Are tetracyclines broad or narrow spectrum? Doxycycline Which generation of tetracyclines name them is part of the triple therapy for H. Two other types of acquired resistance rarely seen include the production of drug-inactivating enzymes esterases or kinasesas well as the production of active ATP-dependent efflux proteins that transport the drug outside of the cell.

Aminoglycosides -- they cause neuromuscular blockade decreased ACh release If a patient enters respiratory arrest due to an aminoglycoside, what can you administer to reverse it? Demeclocyclin it causes nephrogenic diabetes insipidus How are aminoglycosides administered?

Is intrathecal administration allowed for aminoglycosides? Azithromycin has been used to treat strep throat Group A streptococcal GAS infection caused by Streptococcus pyogenes in penicillin-sensitive patients, however macrolide-resistant strains of GAS are not uncommon. Aminoglycosides require an oxygen-dependent transport pathway for entry into cells Are aminoglycosides 'cidal or 'static?

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Neomycin can be taken orally to kill GI bugs because it won't be absorbed from the GI tract Which drug is the first alternative for someone who is penicillin or Beta-lactam allergic? Causes tooth pigmentation, enamel hypoplasia, and stunting of growth.

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Macrolides, mainly erythromycin and clarithromycin, also have a class effect of QT prolongationwhich can lead to torsades de pointes. Macrolides exhibit enterohepatic recycling ; that is, the drug is absorbed in the gut and sent to the liver, only to be excreted into the duodenum in bile from the liver.

There is no oral absorption.

Cephalosporin is another option for these patients. Toxic macrolides[ edit ] A variety of toxic macrolides produced by bacteria have been isolated and characterized, such as the mycolactones.

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Macrolides are not to be used on non-ruminant herbivores, such as horses and rabbits. Cholera Rickettsial diseases rocky mountain spotted fever spirochetes It is important to avoid taking tetracyclines with food.

Macrolides can be administered in a variety of ways that include tablets, capsules, suspensions, injectings and topically.

Unlike penicillin, macrolides have been shown to be effective against Legionella pneumophilamycoplasmamycobacteriasome rickettsiaand chlamydia.

Doxycycline it is eliminated via bile Which is the tetracycline of choice for kidney failure patients? Also, what is the PCN of choice for kidney failure patients? What bugs do tetracyclines target? Neostigmine AChE inhibitor or calcium gluconate Neomycin is topical and never parenteral because of nephrotoxicity.

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You discover he was recently prescribed an antibiotic. What category of antibiotic is the likely culprit of these symptoms? Uses[ edit ] Antibiotic macrolides are used to treat infections caused by Gram-positive bacteria e.

Symptoms of colchicine toxicity include gastrointestinal upset, fever, myalgia, pancytopenia, and organ failure.

Inhibiting Protein Synthesis

Macrolides are actively concentrated within leukocytesand thus are transported into the site of infection. This action is considered to be bacteriostatic.

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Divalent and Trivalent cations chelate the tetracyclines -- calcium, magnesium, aluminum, iron, etc. How else might it be administered and why?

Which is the exception? This can lead to a buildup of the product in the system, thereby causing nausea. Which tetracycline is the only one that crosses into the CNS?